FAF2

Across TCGA patient cohorts, FAF2 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAF2-associated genes across cancer lineages are A-Raf_pS299, PCNA, and Rad50. Each is linked with FAF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FAF2-to-partner and partner-to-FAF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by FAF2-low versus FAF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAF2→partner) and Y-score (partner→FAF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.098	-1.807	.015	.025	3	2
UCEC	PCNA →	+0.228	+1.584	.001	.034	3	2
UCEC	Rad50 →	-0.292	-3.000	<.001	<.001	3	2
UCEC	TFRC →	+0.624	+2.415	<.001	.003	3	2
UCEC	Caspase-8 →	-0.273	-3.143	.001	<.001	3	2
UCEC	4E-BP1 →	+0.452	+3.906	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

A-Raf_pS299 by FAF2 expression — UCEC

Explore this box plot interactively →