Across TCGA pan-cancer cohorts, FAF1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FAF1 data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher FAF1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FAF1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

DLBC, SKCM, and SARC are the cancer types where FAF1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Median	II,III,IV	0.172	0.949	<.001	24	view →
SKCM	OS	Median	III,IV	0.230	0.721	.004	12	view →
SARC	DFS	Median	All	0.121	0.591	.042	3	view →
UCEC	DFS	Median	All	0.946	0.629	.044	2	view →
BLCA	DFS	Median	All	1.000	0.501	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: FAF1 tumor-vs-normal RNA expression · all FAF1 data types