Across TCGA patient cohorts, FAF1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAF1-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and ACC1. Each is linked with FAF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FAF1-to-partner and partner-to-FAF1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAF1→partner) and Y-score (partner→FAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.092	-1.973	.020	.029	3	1
UCEC	eIF4E →	+0.172	+2.459	.038	.019	3	1
UCEC	ACC1 →	+0.443	+1.750	.001	.049	3	1
UCEC	MEK1 →	+0.412	+3.321	.004	.009	3	1
UCEC	mTOR_pS2448 →	-0.126	-3.308	.031	.009	3	1
UCEC	Notch1 →	+0.305	+3.169	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

FAF1 survival (RNA) · tumor vs normal (RNA) · all FAF1 data types