FADS6

Across TCGA patient cohorts, FADS6 mutation is significantly associated with the RNA expression of many other genes, with 295 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FADS6-associated genes across cancer lineages are PLCE1P1, RN7SL764P, and RNA5SP455. Each is linked with FADS6 in more than 1 cancer types. Because this analysis shows association rather than direction, both FADS6-to-partner and partner-to-FADS6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLCE1P1 grouped by FADS6-low versus FADS6-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FADS6→partner) and Y-score (partner→FADS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PLCE1P1 →	+0.239	+7.731	<.001	.009	3	2
SKCM	RN7SL764P →	+0.084	+3.436	<.001	.005	3	2
UCEC	RNA5SP455 →	+0.226	+4.010	<.001	.007	3	2
UCEC	LINC02089 →	+0.075	+2.957	.005	.009	3	2
UCEC	RPL31P47 →	+0.481	+2.706	<.001	.003	3	2
UCEC	RN7SL384P →	+0.279	+2.398	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 295 associations by consensus.

PLCE1P1 by FADS6 expression — BRCA

Explore this box plot interactively →