FADS2

Across TCGA patient cohorts, FADS2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FADS2-associated genes across cancer lineages are C-Raf, 4E-BP1_pT70, and Cyclin-E2. Each is linked with FADS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FADS2-to-partner and partner-to-FADS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by FADS2-low versus FADS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FADS2→partner) and Y-score (partner→FADS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.250	+3.459	<.001	.005	3	2
COAD	4E-BP1_pT70 →	+0.182	+3.178	.001	.010	3	2
COAD	Cyclin-E2 →	+0.255	+2.832	.025	.034	3	2
UCEC	EGFR_pY1068 →	-0.271	-2.321	.031	.035	3	1
UCEC	MEK1 →	+0.371	+3.000	.043	.036	3	1
UCEC	Notch1 →	+0.232	+2.321	.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

C-Raf by FADS2 expression — UCEC

Explore this box plot interactively →