FADS2

Across TCGA cell cohorts, FADS2 mutation is significantly associated with the mutation status of many other genes, with 3,755 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FADS2-associated genes across cancer lineages are RAD18, ZBED4, and RHBDL1. Each is linked with FADS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both FADS2-to-partner and partner-to-FADS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD18 grouped by FADS2-low versus FADS2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FADS2→partner) and Y-score (partner→FADS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RAD18 →	+3.137	+3.807	.001	.001	1	3
BLOOD_Leukemia	ZBED4 →	+3.430	+4.545	<.001	<.001	1	3
BLOOD_Leukemia	RHBDL1 →	+3.845	+4.235	<.001	<.001	1	3
BLOOD_Leukemia	CYP27B1 →	+3.108	+3.108	.008	.008	1	3
LARGE_INTESTINE	RPS6KC1 →	+2.459	+3.321	.005	.005	1	3
BLOOD_Leukemia	RGS3 →	+3.260	+3.498	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,755 associations by consensus.

RAD18 by FADS2 expression — LARGE_INTESTINE

Explore this box plot interactively →