FADS1

Across TCGA patient cohorts, FADS1 mutation is significantly associated with the RNA expression of many other genes, with 407 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FADS1-associated genes across cancer lineages are TTTY2, TRAJ27, and RNA5SP367. Each is linked with FADS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FADS1-to-partner and partner-to-FADS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTTY2 grouped by FADS1-low versus FADS1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FADS1→partner) and Y-score (partner→FADS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TTTY2 →	+0.014	+7.954	<.001	.008	3	2
LUSC	TRAJ27 →	+0.862	+4.187	<.001	.009	3	2
BLCA	RNA5SP367 →	+0.385	+5.038	<.001	.009	3	2
CESC	TAAR2 →	+0.038	+6.342	<.001	.001	3	1
CESC	LCN1P2 →	+0.204	+6.569	<.001	.001	3	1
CESC	DNAJA1P1 →	+0.036	+5.306	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 407 associations by consensus.

TTTY2 by FADS1 expression — HNSC

Explore this box plot interactively →