FADD

Across TCGA pan-cancer cohorts, FADD mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated FADD data layer compared with 28 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher FADD mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FADD expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

LSCC, GBM, and PDAC are the cancer types where FADD mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.652	0.895	.005	28	view →
GBM	DFS	Quartile	All	0.182	0.362	.018	9	view →
PDAC	OS	Quartile	III,IV	0.977	0.403	.027	5	view →
LUAD	OS	Quartile	All	0.453	0.829	.022	4	view →
CCRCC	OS	Quartile	II,III,IV	0.687	0.953	.007	4	view →
HNSC	DFS	Median	IV	0.328	0.889	.014	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

FADD–LSCC (DFS)

Open the LSCC breakdown →