FADD

Across TCGA patient cohorts, FADD mutation is significantly associated with the RNA expression of many other genes, with 136 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FADD-associated genes across cancer lineages are CCDC140, RNA5SP375, and RPL17P49. Each is linked with FADD in more than 1 cancer types. Because this analysis shows association rather than direction, both FADD-to-partner and partner-to-FADD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC140 grouped by FADD-low versus FADD-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FADD→partner) and Y-score (partner→FADD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	CCDC140 →	+0.324	+4.234	<.001	.008	3	2
CESC	RNA5SP375 →	+0.277	+5.837	<.001	.001	3	2
LUAD	RPL17P49 →	+0.163	+5.984	<.001	.002	3	2
COAD	FTLP16 →	+0.108	+5.283	.007	.006	3	2
UCEC	RNF166 →	+0.644	+3.343	<.001	.005	3	1
UCEC	DOLPP1 →	+0.588	+3.332	.008	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 136 associations by consensus.

CCDC140 by FADD expression — CESC

Explore this box plot interactively →