FADD

Across TCGA patient cohorts, FADD mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FADD-associated genes across cancer lineages are EGFR_pY1068, S6_pS240_S244, and VHL. Each is linked with FADD in more than 1 cancer types. Because this analysis shows association rather than direction, both FADD-to-partner and partner-to-FADD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by FADD-low versus FADD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FADD→partner) and Y-score (partner→FADD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.352	-3.000	.015	.037	3	1
UCEC	S6_pS240_S244 →	+0.487	+3.000	.038	.037	3	1
UCEC	VHL →	-1.286	-3.000	.001	.037	3	1
UCEC	Di-Ras3 →	-0.246	-3.000	.004	.037	2	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.751	+3.000	.010	.037	1	1
UCEC	Rab25 →	-0.378	-3.000	.048	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by FADD expression — UCEC

Explore this box plot interactively →