F8A2

Across TCGA pan-cancer cohorts, F8A2 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of F8A2’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where F8A2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types F8A2 is over-expressed in tumor, although a few such as KIRP show the opposite, repressed pattern.

BRCA, STAD, and KIRP are the cancer types where F8A2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in F8A2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	II,III,IV	+0.008	.004	4	view →
STAD	All	II,III,IV	+0.081	.017	2	view →
KIRP	All	III,IV	−0.012	.033	2	view →
LUSC	Male	All	+0.010	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

F8A2–BRCA

Open the BRCA breakdown →