F8A1

Across TCGA pan-cancer cohorts, F8A1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated F8A1 data layer.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher F8A1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated F8A1 expression acts as an unfavorable survival marker, although some lineages such as CESC and UVM show a favorable association.

CESC, MESO, and COAD are the cancer types where F8A1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Tertile	All	0.816	0.467	<.001	80	view →
MESO	OS	Quartile	All	0.380	0.602	<.001	54	view →
COAD	DFS	Tertile	III,IV	0.408	0.786	.001	46	view →
UVM	DFS	Tertile	All	0.877	0.430	.007	28	view →
ESCA	DFS	Median	IV	0.634	0.205	.006	24	view →
LIHC	DFS	Median	All	0.359	0.521	.001	21	view →
SARC	OS	Tertile	All	0.679	0.325	.001	15	view →
OV	OS	Quartile	II,III,IV	0.744	0.633	.019	10	view →
THCA	DFS	Tertile	II,III,IV	0.901	0.325	.013	9	view →
READ	OS	Median	IV	0.824	0.466	.006	5	view →
KIRP	DFS	Median	II,III,IV	0.723	0.322	.014	5	view →
PAAD	OS	Median	III,IV	0.629	1.000	.022	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

F8A1–CESC (OS)

Open the CESC breakdown →