F7

Across TCGA patient cohorts, F7 mutation is significantly associated with the RNA expression of many other genes, with 2,534 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible F7-associated genes across cancer lineages are POLE2, LPIN2, and ATG4A. Each is linked with F7 in more than 1 cancer types. Because this analysis shows association rather than direction, both F7-to-partner and partner-to-F7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLE2 grouped by F7-low versus F7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (F7→partner) and Y-score (partner→F7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	POLE2 →	+0.472	+3.343	.008	.005	3	2
UCEC	LPIN2 →	+0.533	+2.098	.006	.003	3	2
UCEC	ATG4A →	+0.539	+3.247	<.001	<.001	3	2
UCEC	DOT1L →	+0.639	+2.606	<.001	<.001	3	2
UCEC	BCL7B →	+0.385	+4.343	<.001	<.001	3	2
UCEC	MCM3 →	+0.597	+2.087	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,534 associations by consensus.

POLE2 by F7 expression — UCEC

Explore this box plot interactively →