F7

Across TCGA patient cohorts, F7 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible F7-associated genes across cancer lineages are MEK1, Notch1, and Di-Ras3. Each is linked with F7 in more than 1 cancer types. Because this analysis shows association rather than direction, both F7-to-partner and partner-to-F7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by F7-low versus F7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (F7→partner) and Y-score (partner→F7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.416	+3.584	.003	.002	3	2
UCEC	Notch1 →	+0.119	+2.000	.031	.010	3	2
UCEC	Di-Ras3 →	-0.126	-2.986	.030	.035	3	2
UCEC	JNK2 →	+0.319	+3.594	<.001	.001	3	1
UCEC	Ku80 →	+0.203	+1.598	.028	.022	3	1
UCEC	p27_pT198 →	+0.086	+1.584	.039	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

MEK1 by F7 expression — UCEC

Explore this box plot interactively →