Across TCGA pan-cancer cohorts, F5 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated F5 data layer compared with 24 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher F5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated F5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

SCLC, UCEC, and PRAD are the cancer types where F5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	III,IV	0.055	0.640	<.001	12	view →
UCEC	DFS	Median	II,III,IV	0.854	0.433	.040	10	view →
PRAD	DFS	Median	All	0.085	0.774	.001	6	view →
LUAD	DFS	Median	IV	0.047	0.565	<.001	6	view →
BLCA	OS	Median	IV	0.783	0.241	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: F5 tumor-vs-normal RNA expression · all F5 data types