Across TCGA patient cohorts, F5 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible F5-associated genes across cancer lineages are Caspase-7-cleavedD198, Syk, and HER3_pY1289. Each is linked with F5 in more than 4 cancer types. Because this analysis shows association rather than direction, both F5-to-partner and partner-to-F5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (F5→partner) and Y-score (partner→F5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.698	+2.137	<.001	<.001	3	5
STAD	Syk →	+0.389	+3.169	.045	.019	3	3
BLCA	HER3_pY1289 →	+0.123	+2.459	.018	.020	3	3
UCEC	JNK_pT183_Y185 →	-0.145	-1.459	.001	.011	3	3
UCEC	MSH2 →	-0.261	-1.674	<.001	.001	3	3
COAD	ATM →	-0.657	-3.000	<.001	.034	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

Exploration

F5 survival (RNA) · tumor vs normal (RNA) · all F5 data types