F3

Across TCGA pan-cancer cohorts, F3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated F3 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher F3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated F3 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, LUAD, and CCRCC are the cancer types where F3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.289	0.523	<.001	95	view →
LUAD	OS	Median	All	0.612	0.917	<.001	46	view →
CCRCC	OS	Median	III,IV	0.445	0.875	.001	8	view →
GBM	DFS	Tertile	All	0.198	0.483	.004	8	view →
HNSC	DFS	Quartile	IV	0.857	0.584	.020	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

F3–PDAC (DFS)

Open the PDAC breakdown →