F3

Across TCGA patient cohorts, F3 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible F3-associated genes across cancer lineages are JNK2, NDRG1_pT346, and p62 Lck ligand. Each is linked with F3 in more than 1 cancer types. Because this analysis shows association rather than direction, both F3-to-partner and partner-to-F3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by F3-low versus F3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (F3→partner) and Y-score (partner→F3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.309	+3.169	.004	.020	3	1
UCEC	NDRG1_pT346 →	-0.586	-3.000	.029	.036	3	1
UCEC	p62 Lck ligand →	+0.742	+3.009	<.001	.019	3	1
UCEC	STAT3_pY705 →	-0.578	-2.990	<.001	.036	2	1
UCEC	BRD4 →	+0.416	+3.007	.007	.019	2	1
UCEC	eIF4E →	+0.337	+3.169	.003	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

JNK2 by F3 expression — UCEC

Explore this box plot interactively →