F2RL2

Across TCGA patient cohorts, F2RL2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible F2RL2-associated genes across cancer lineages are STAT3_pY705, p38-MAPK_pT180_Y182, and AMPK_alpha. Each is linked with F2RL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both F2RL2-to-partner and partner-to-F2RL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by F2RL2-low versus F2RL2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (F2RL2→partner) and Y-score (partner→F2RL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	STAT3_pY705 →	-0.380	-3.000	.014	.036	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.596	-2.308	.008	.036	2	2
SKCM	AMPK_alpha →	+0.313	+3.000	<.001	.036	3	1
SKCM	Annexin_VII →	-0.181	-3.000	.034	.036	3	1
SKCM	Src →	-0.444	-3.000	<.001	.036	3	1
UCEC	eEF2 →	+0.576	+2.321	.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

STAT3_pY705 by F2RL2 expression — SKCM

Explore this box plot interactively →