F2RL2

Across TCGA cell cohorts, F2RL2 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible F2RL2-associated genes across cancer lineages are ACKR1, CLEC10A, and OR5T1. Each is linked with F2RL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both F2RL2-to-partner and partner-to-F2RL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACKR1 grouped by F2RL2-low versus F2RL2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (F2RL2→partner) and Y-score (partner→F2RL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACKR1 →	+0.065	+4.032	<.001	.004	3	1
SKIN	CLEC10A →	+0.033	+4.273	<.001	.006	3	1
SKIN	OR5T1 →	+0.014	+4.415	<.001	.007	3	1
SKIN	GALP →	+0.017	+4.415	<.001	.007	3	1
SKIN	TEX49 →	+0.033	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ACKR1 by F2RL2 expression — LARGE_INTESTINE

Explore this box plot interactively →