F2RL2

Across TCGA cell cohorts, F2RL2 mutation is significantly associated with the mutation status of many other genes, with 4,044 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible F2RL2-associated genes across cancer lineages are CHTOP, FAP, and PTPRC. Each is linked with F2RL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both F2RL2-to-partner and partner-to-F2RL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHTOP grouped by F2RL2-low versus F2RL2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (F2RL2→partner) and Y-score (partner→F2RL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CHTOP →	+5.053	+4.239	.007	.007	1	3
LARGE_INTESTINE	FAP →	+2.630	+3.047	.005	.005	1	2
LARGE_INTESTINE	PTPRC →	+2.478	+4.392	<.001	<.001	1	2
SKIN	CADPS2 →	+3.053	+3.718	.006	.006	1	2
LARGE_INTESTINE	OVGP1 →	+3.215	+3.954	<.001	<.001	1	2
SKIN	BICRA →	+2.830	+3.548	.009	.009	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,044 associations by consensus.

CHTOP by F2RL2 expression — SKIN

Explore this box plot interactively →