F2

Across TCGA pan-cancer cohorts, F2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated F2 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher F2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated F2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

UCEC, COAD, and LUAD are the cancer types where F2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	III,IV	0.232	1.000	.002	32	view →
COAD	DFS	Median	All	0.879	1.000	.014	30	view →
LUAD	OS	Median	III,IV	0.225	0.764	.002	26	view →
GBM	OS	Median	All	0.258	0.491	.008	8	view →
LSCC	DFS	Tertile	II,III,IV	0.816	1.000	.008	7	view →
CCRCC	DFS	Quartile	III,IV	0.755	0.276	.018	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

F2–UCEC (DFS)

Open the UCEC breakdown →