F2

Across TCGA patient cohorts, F2 protein abundance is significantly associated with the RNA expression of many other genes, with 13,406 significant associations in total. GBM shows the largest number of these associations.

The most reproducible F2-associated genes across cancer lineages are SERPINE1, FLT1, and IL6. Each is linked with F2 in more than 8 cancer types. Because this analysis shows association rather than direction, both F2-to-partner and partner-to-F2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, F2 versus SERPINE1 in GBM, with a Pearson correlation of 0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (F2→partner) and Y-score (partner→F2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SERPINE1 →	+1.519	+0.505	<.001	<.001	3	9
COAD	FLT1 →	+0.849	+0.753	<.001	<.001	3	8
LSCC	IL6 →	+1.647	+0.514	<.001	<.001	3	8
OV	VEGFC →	+0.843	+0.569	<.001	<.001	3	8
OV	MMP19 →	+1.308	+0.706	<.001	<.001	3	7
OV	LRRC32 →	+0.922	+0.488	.001	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,406 associations by consensus.

F2 vs SERPINE1 — GBM

Explore this scatter interactively →