F2

Across TCGA patient cohorts, F2 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible F2-associated genes across cancer lineages are EGFR_pY1068, INPP4B, and ARID1A. Each is linked with F2 in more than 1 cancer types. Because this analysis shows association rather than direction, both F2-to-partner and partner-to-F2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by F2-low versus F2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (F2→partner) and Y-score (partner→F2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EGFR_pY1068 →	-0.393	-2.450	.005	.020	3	1
COAD	INPP4B →	-0.491	-2.450	.002	.020	3	1
COAD	ARID1A →	+0.179	+2.825	.019	.033	3	1
COAD	Bcl-xL →	-0.260	-2.433	.012	.020	2	2
UCEC	ERK2 →	+0.169	+3.169	.025	.018	3	1
UCEC	FOXO3a_pS318_S321 →	-0.127	-2.105	.009	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

EGFR_pY1068 by F2 expression — COAD

Explore this box plot interactively →