F2

Across TCGA cell cohorts, F2 mutation is significantly associated with the mutation status of many other genes, with 5,793 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible F2-associated genes across cancer lineages are TXNRD1, ZCCHC14, and GIGYF1. Each is linked with F2 in more than 3 cancer types. Because this analysis shows association rather than direction, both F2-to-partner and partner-to-F2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TXNRD1 grouped by F2-low versus F2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (F2→partner) and Y-score (partner→F2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TXNRD1 →	+2.823	+3.665	.008	.008	1	4
LARGE_INTESTINE	ZCCHC14 →	+2.736	+3.208	.001	.001	1	4
BLOOD_Leukemia	GIGYF1 →	+2.975	+4.741	<.001	<.001	1	4
BREAST	ARHGEF17 →	+3.558	+3.095	.008	.008	1	3
BREAST	SYNJ1 →	+3.558	+3.095	.008	.008	1	3
BREAST	PLEKHM1 →	+4.974	+3.925	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,793 associations by consensus.

TXNRD1 by F2 expression — BLOOD_Leukemia

Explore this box plot interactively →