F12

Across TCGA pan-cancer cohorts, F12 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated F12 data layer compared with 27 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher F12 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated F12 expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

UCEC and BLCA are the cancer types where F12 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
BLCA	DFS	Median	II,III,IV	1.000	0.506	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

F12–UCEC (OS)

Open the UCEC breakdown →