F12

Across TCGA pan-cancer cohorts, F12 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated F12 data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher F12 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated F12 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

LSCC, PDAC, and CCRCC are the cancer types where F12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.519	0.948	.003	27	view →
PDAC	OS	Median	IV	0.836	0.491	.024	5	view →
CCRCC	OS	Tertile	All	1.000	0.872	.034	4	view →
UCEC	DFS	Tertile	III,IV	0.529	1.000	.049	4	view →
LUAD	OS	Median	All	0.912	0.972	.025	3	view →
HNSC	DFS	Quartile	III,IV	1.000	0.875	.020	3	view →
GBM	OS	Tertile	All	0.268	0.541	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

F12–LSCC (DFS)

Open the LSCC breakdown →