EZR

Across TCGA patient cohorts, EZR mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EZR-associated genes across cancer lineages are eEF2, Gab2, and p70-S6K_pT389. Each is linked with EZR in more than 2 cancer types. Because this analysis shows association rather than direction, both EZR-to-partner and partner-to-EZR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by EZR-low versus EZR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EZR→partner) and Y-score (partner→EZR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.405	+1.847	.002	.008	3	3
UCEC	Gab2 →	+0.347	+2.115	.008	.017	3	2
UCEC	p70-S6K_pT389 →	-0.205	-3.700	.003	.001	3	2
UCEC	ATM →	-0.695	-2.736	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.822	+3.827	<.001	<.001	3	2
UCEC	C-Raf →	+0.159	+2.321	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

eEF2 by EZR expression — UCEC

Explore this box plot interactively →