EZR

Across TCGA cell cohorts, EZR mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EZR-associated genes across cancer lineages are PRSS58, ODF1, and OR52K1. Each is linked with EZR in more than 1 cancer types. Because this analysis shows association rather than direction, both EZR-to-partner and partner-to-EZR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS58 grouped by EZR-low versus EZR-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EZR→partner) and Y-score (partner→EZR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PRSS58 →	+0.092	+5.000	<.001	.006	3	1
SKIN	ODF1 →	+0.020	+5.022	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR52K1 →	+0.015	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	DPPA5 →	+0.055	+4.544	<.001	.003	3	1
LARGE_INTESTINE	BPIFB6 →	+0.016	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR2AT4 →	+0.015	+3.196	.006	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

PRSS58 by EZR expression — PANCREAS

Explore this box plot interactively →