EZH2

Across TCGA patient cohorts, EZH2 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EZH2-associated genes across cancer lineages are ATM, ACC1, and PCNA. Each is linked with EZH2 in more than 3 cancer types. Because this analysis shows association rather than direction, both EZH2-to-partner and partner-to-EZH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by EZH2-low versus EZH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EZH2→partner) and Y-score (partner→EZH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.532	-2.057	<.001	.001	3	4
COAD	ACC1 →	+0.491	+2.330	.005	.020	3	3
UCEC	PCNA →	+0.224	+2.736	<.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.495	+2.087	.001	.004	3	3
UCEC	4E-BP1 →	+0.268	+2.502	<.001	.001	3	2
COAD	Di-Ras3 →	-0.188	-3.000	.032	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

ATM by EZH2 expression — UCEC

Explore this box plot interactively →