EZH2

Across TCGA cell cohorts, EZH2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,700 significant associations in total. BONE shows the largest number of these associations.

The most reproducible EZH2-associated GO terms across cancer lineages are Replication fork processing, Interstrand cross-link repair, and DNA replication initiation. Each is linked with EZH2 in more than 18 cancer types. Because this analysis shows association rather than direction, both EZH2-to-partner and partner-to-EZH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Replication fork processing grouped by EZH2-low versus EZH2-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EZH2→partner) and Y-score (partner→EZH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Replication fork processing →	+0.103	+1.347	.001	<.001	3	19
PANCREAS	Interstrand cross-link repair →	+0.085	+1.430	<.001	<.001	3	19
BONE	DNA replication initiation →	+0.221	+2.235	.001	<.001	3	19
BONE	Mitotic DNA replication checkpoint signaling →	+0.238	+2.231	<.001	<.001	3	19
BONE	Negative regulation of G2/M transition of mitotic cell cycle →	+0.097	+1.879	.001	.004	3	18
BONE	Regulation of cell cycle G2/M phase transition →	+0.099	+2.016	.001	.004	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,700 associations by consensus.

Replication fork processing by EZH2 expression — BLOOD_Myeloma

Explore this box plot interactively →