EZH2

Across TCGA cell cohorts, EZH2 mutation is significantly associated with the RNA expression of many other genes, with 566 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible EZH2-associated genes across cancer lineages are ACAP2, RBMS1, and WDR87. Each is linked with EZH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EZH2-to-partner and partner-to-EZH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACAP2 grouped by EZH2-low versus EZH2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EZH2→partner) and Y-score (partner→EZH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ACAP2 →	+1.169	+3.169	<.001	.008	3	2
BLOOD_Lymphoma	RBMS1 →	-1.992	-3.321	<.001	.006	3	2
BLOOD_Lymphoma	WDR87 →	+0.024	+2.855	.007	<.001	3	2
BLOOD_Lymphoma	KIF24 →	+0.781	+3.321	<.001	.006	3	2
BLOOD_Lymphoma	NCR3LG1 →	+2.044	+3.321	<.001	.004	3	2
BLOOD_Lymphoma	SMIM20 →	+1.013	+3.321	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 566 associations by consensus.

ACAP2 by EZH2 expression — BLOOD_Lymphoma

Explore this box plot interactively →