EZH1

Across TCGA patient cohorts, EZH1 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EZH1-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and Cyclin-B1. Each is linked with EZH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EZH1-to-partner and partner-to-EZH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by EZH1-low versus EZH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EZH1→partner) and Y-score (partner→EZH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.273	+1.502	.024	.027	3	2
UCEC	Caspase-7-cleavedD198 →	+0.505	+1.434	.011	.027	3	2
UCEC	Cyclin-B1 →	+0.495	+2.700	.008	.005	3	2
UCEC	14-3-3_beta →	-0.093	-2.388	.005	.002	3	1
UCEC	eEF2 →	+0.331	+1.700	.005	.040	3	1
UCEC	EGFR_pY1068 →	-0.218	-1.584	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

ASNS by EZH1 expression — UCEC

Explore this box plot interactively →