EZH1

Across TCGA cell cohorts, EZH1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,414 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EZH1-associated GO terms across cancer lineages are Subtelomeric heterochromatin formation, Microtubule nucleation, and Cytosolic transport. Each is linked with EZH1 in more than 16 cancer types. Because this analysis shows association rather than direction, both EZH1-to-partner and partner-to-EZH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Subtelomeric heterochromatin formation grouped by EZH1-low versus EZH1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EZH1→partner) and Y-score (partner→EZH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Subtelomeric heterochromatin formation →	+0.129	+1.049	<.001	<.001	3	17
BONE	Microtubule nucleation →	+0.135	+1.204	<.001	<.001	3	15
SKIN	Cytosolic transport →	+0.071	+0.700	<.001	<.001	3	15
KIDNEY	Protein localization to chromosome, telomeric region →	+0.114	+1.250	<.001	<.001	3	15
LUNG_SCLC	Constitutive heterochromatin formation →	+0.122	+0.987	<.001	<.001	3	14
BONE	Pre-mRNA catabolic process →	+0.210	+1.159	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,414 associations by consensus.

Subtelomeric heterochromatin formation by EZH1 expression — BONE

Explore this box plot interactively →