EYA4

Across TCGA pan-cancer cohorts, EYA4 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated EYA4 data layer compared with 25 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher EYA4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated EYA4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

UCS, UCEC, and HNSC are the cancer types where EYA4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	All	0.068	0.524	<.001	48	view →
UCEC	DFS	Median	All	0.964	0.823	.004	32	view →
HNSC	OS	Median	All	0.169	0.714	<.001	18	view →
LGG	DFS	Median	All	0.230	0.753	.005	12	view →
SARC	DFS	Median	All	0.038	0.611	<.001	12	view →
COAD	DFS	Median	IV	0.035	0.501	<.001	6	view →
PRAD	DFS	Median	All	0.187	0.777	.008	4	view →
STAD	DFS	Median	III,IV	1.000	0.574	.039	4	view →
BLCA	OS	Median	IV	0.141	0.573	.034	3	view →
SKCM	OS	Median	II,III,IV	0.494	0.290	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

EYA4–UCS (DFS)

Open the UCS breakdown →