EYA4

Across TCGA patient cohorts, EYA4 mutation is significantly associated with the RNA expression of many other genes, with 4,745 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EYA4-associated genes across cancer lineages are CEP55, SLC22A3, and BUB1B. Each is linked with EYA4 in more than 3 cancer types. Because this analysis shows association rather than direction, both EYA4-to-partner and partner-to-EYA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEP55 grouped by EYA4-low versus EYA4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EYA4→partner) and Y-score (partner→EYA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CEP55 →	+0.519	+3.335	.007	.005	3	4
COAD	SLC22A3 →	-0.793	-3.574	.001	.002	3	4
COAD	BUB1B →	+0.522	+2.615	.005	.005	3	4
UCEC	RAD51 →	+0.706	+1.711	<.001	<.001	3	4
UCEC	PPP2R2D →	+0.183	+1.625	.006	.001	3	4
UCEC	DRAP1 →	+0.297	+1.862	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,745 associations by consensus.

CEP55 by EYA4 expression — COAD

Explore this box plot interactively →