EYA4

Across TCGA patient cohorts, EYA4 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EYA4-associated genes across cancer lineages are 4E-BP1, MSH6, and eIF4E. Each is linked with EYA4 in more than 3 cancer types. Because this analysis shows association rather than direction, both EYA4-to-partner and partner-to-EYA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by EYA4-low versus EYA4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EYA4→partner) and Y-score (partner→EYA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	4E-BP1 →	+0.398	+2.459	.003	.020	3	3
LUAD	MSH6 →	+0.291	+3.025	.032	.018	3	2
UCEC	eIF4E →	+0.155	+2.235	.006	.005	3	2
UCEC	Heregulin →	-0.093	-1.571	.005	.015	3	2
UCEC	MEK1 →	+0.410	+1.584	<.001	<.001	3	2
UCEC	PCNA →	+0.186	+2.502	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

4E-BP1 by EYA4 expression — LUAD

Explore this box plot interactively →