EYA4

Across TCGA cell cohorts, EYA4 mutation is significantly associated with the RNA expression of many other genes, with 195 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EYA4-associated genes across cancer lineages are PIP, OR6N1, and LCE1F. Each is linked with EYA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both EYA4-to-partner and partner-to-EYA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIP grouped by EYA4-low versus EYA4-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EYA4→partner) and Y-score (partner→EYA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PIP →	+0.040	+4.807	<.001	.006	3	1
BLOOD_Myeloma	OR6N1 →	+0.136	+4.807	<.001	.006	3	1
BLOOD_Myeloma	LCE1F →	+0.166	+4.807	<.001	.006	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
LUNG_SCLC	SHISA6 →	+0.602	+3.070	<.001	.009	3	1
SKIN	UGT2B10 →	+0.006	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 195 associations by consensus.

PIP by EYA4 expression — BLOOD_Myeloma

Explore this box plot interactively →