EYA3

Across TCGA pan-cancer cohorts, EYA3 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of EYA3’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where EYA3 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types EYA3 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

LSCC, LUAD, and HNSC are the cancer types where EYA3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EYA3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	+0.597	<.001	9	view →
LUAD	All	III,IV	+0.332	<.001	9	view →
HNSC	Male	IV	+0.293	<.001	8	view →
CCRCC	Male	All	−0.091	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

EYA3–LSCC

Open the LSCC breakdown →