EYA1

Across TCGA pan-cancer cohorts, EYA1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated EYA1 data layer compared with 21 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher EYA1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated EYA1 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

PDAC, CCRCC, and LSCC are the cancer types where EYA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.628	0.907	.004	18	view →
CCRCC	DFS	Median	II,III,IV	0.619	0.865	.030	6	view →
LSCC	DFS	Tertile	III,IV	0.908	0.404	.017	6	view →
HNSC	DFS	Tertile	III,IV	0.758	0.959	.021	5	view →
LUAD	DFS	Median	II,III,IV	0.740	1.000	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

EYA1–PDAC (DFS)

Open the PDAC breakdown →