EYA1

Across TCGA patient cohorts, EYA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,153 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible EYA1-associated GO terms across cancer lineages are Positive regulation of response to endoplasmic reticulum stress, Nucleus organization, and Regulation of nucleotide-excision repair. Each is linked with EYA1 in more than 23 cancer types. Because this analysis shows association rather than direction, both EYA1-to-partner and partner-to-EYA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of response to endoplasmic reticulum stress grouped by EYA1-low versus EYA1-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EYA1→partner) and Y-score (partner→EYA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Positive regulation of response to endoplasmic reticulum stress →	+0.056	+0.192	<.001	<.001	3	24
LAML	Nucleus organization →	+0.046	+0.522	<.001	<.001	3	23
TGCT	Regulation of nucleotide-excision repair →	+0.055	+1.284	<.001	<.001	3	22
STAD	mRNA transport →	+0.067	+0.297	<.001	<.001	3	22
ESCA	Regulation of microtubule cytoskeleton organization →	+0.055	+0.421	<.001	.003	2	23
STAD	Regulation of telomere maintenance via telomere lengthening →	+0.049	+0.226	<.001	<.001	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,153 associations by consensus.

Positive regulation of response to endoplasmic reticulum stress by EYA1 expression — STAD

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