EYA1

Across TCGA patient cohorts, EYA1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EYA1-associated genes across cancer lineages are ARID1A, JNK_pT183_Y185, and JNK2. Each is linked with EYA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EYA1-to-partner and partner-to-EYA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARID1A grouped by EYA1-low versus EYA1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EYA1→partner) and Y-score (partner→EYA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ARID1A →	-0.117	-2.292	.042	.033	2	3
UCEC	JNK_pT183_Y185 →	-0.127	-1.392	.008	.017	3	2
UCEC	JNK2 →	+0.195	+1.398	<.001	.004	3	2
UCEC	STAT5a →	+0.251	+1.054	.027	.029	3	2
UCEC	Chk2_pT68 →	-0.145	-2.060	.006	.001	3	2
UCEC	c-Kit →	-0.189	-1.222	.004	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ARID1A by EYA1 expression — SKCM

Explore this box plot interactively →