EYA1

Across TCGA cell cohorts, EYA1 mutation is significantly associated with the RNA expression of many other genes, with 48 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible EYA1-associated genes across cancer lineages are FAM205A, ACER1, and WFDC13. Each is linked with EYA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EYA1-to-partner and partner-to-EYA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM205A grouped by EYA1-low versus EYA1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EYA1→partner) and Y-score (partner→EYA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM205A →	+0.019	+3.766	.001	.004	3	3
LARGE_INTESTINE	ACER1 →	+0.083	+4.145	.003	.001	3	2
LUNG_SCLC	WFDC13 →	+0.161	+2.906	<.001	.007	3	2
LARGE_INTESTINE	PRAMEF20 →	+0.010	+4.022	<.001	.006	3	2
CNS	POM121L2 →	+0.058	+3.816	.003	.004	3	2
LUNG_NSCLC_LUAD	TAS2R40 →	+0.054	+3.593	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

FAM205A by EYA1 expression — LARGE_INTESTINE

Explore this box plot interactively →