EYA1

Across TCGA cell cohorts, EYA1 mutation is significantly associated with the mutation status of many other genes, with 4,781 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EYA1-associated genes across cancer lineages are SHROOM2, PTPRB, and PDE4C. Each is linked with EYA1 in more than 4 cancer types. Because this analysis shows association rather than direction, both EYA1-to-partner and partner-to-EYA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SHROOM2 grouped by EYA1-low versus EYA1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EYA1→partner) and Y-score (partner→EYA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SHROOM2 →	+4.502	+5.066	.007	.007	1	5
SOFT_TISSUE	PTPRB →	+4.502	+5.066	.007	.007	1	5
CNS	PDE4C →	+5.000	+4.044	.008	.008	1	4
SOFT_TISSUE	HECW2 →	+4.502	+5.066	.007	.007	1	4
CNS	CEP170 →	+5.000	+4.044	.008	.008	1	4
CNS	DENND4A →	+4.000	+4.000	.002	.002	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,781 associations by consensus.

SHROOM2 by EYA1 expression — SOFT_TISSUE

Explore this box plot interactively →