EXTL3

Across TCGA patient cohorts, EXTL3 mutation is significantly associated with the RNA expression of many other genes, with 5,401 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXTL3-associated genes across cancer lineages are SEC13, ATP5IF1, and GAS2L1. Each is linked with EXTL3 in more than 3 cancer types. Because this analysis shows association rather than direction, both EXTL3-to-partner and partner-to-EXTL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEC13 grouped by EXTL3-low versus EXTL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXTL3→partner) and Y-score (partner→EXTL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEC13 →	+0.389	+2.695	<.001	<.001	3	4
UCEC	ATP5IF1 →	+0.301	+2.098	.006	.002	3	4
COAD	GAS2L1 →	+0.786	+2.710	<.001	.003	3	3
COAD	CPNE1 →	-0.719	-2.687	.004	.006	3	3
COAD	LINC00865 →	-0.396	-2.687	.009	.006	3	3
LUSC	HMGB1P22 →	+0.268	+3.565	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,401 associations by consensus.

SEC13 by EXTL3 expression — UCEC

Explore this box plot interactively →