EXTL3

Across TCGA patient cohorts, EXTL3 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXTL3-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and JNK2. Each is linked with EXTL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both EXTL3-to-partner and partner-to-EXTL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by EXTL3-low versus EXTL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXTL3→partner) and Y-score (partner→EXTL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.385	+1.906	.001	.014	3	3
UCEC	Caspase-7-cleavedD198 →	+0.474	+1.434	.013	.027	3	3
UCEC	JNK2 →	+0.266	+2.321	<.001	<.001	3	2
UCEC	MEK1 →	+0.416	+2.000	<.001	<.001	3	2
UCEC	Annexin-1 →	+0.774	+4.087	<.001	<.001	3	2
SKCM	Src →	-0.214	-2.442	.012	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

ASNS by EXTL3 expression — UCEC

Explore this box plot interactively →