EXTL3

Across TCGA cell cohorts, EXTL3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,398 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EXTL3-associated GO terms across cancer lineages are Nuclear transport, Nucleocytoplasmic transport, and Negative regulation of keratinocyte differentiation. Each is linked with EXTL3 in more than 12 cancer types. Because this analysis shows association rather than direction, both EXTL3-to-partner and partner-to-EXTL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear transport grouped by EXTL3-low versus EXTL3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EXTL3→partner) and Y-score (partner→EXTL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Nuclear transport →	+0.069	+1.081	.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Nucleocytoplasmic transport →	+0.069	+1.116	.001	<.001	3	13
LUNG_SCLC	Negative regulation of keratinocyte differentiation →	+0.193	+1.670	<.001	<.001	3	13
LARGE_INTESTINE	Negative regulation of myoblast fusion →	+0.094	+1.110	<.001	<.001	3	13
BLOOD_Myeloma	Nucleic acid transport →	+0.079	+1.206	.003	<.001	3	12
BLOOD_Myeloma	RNA transport →	+0.079	+1.206	.003	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,398 associations by consensus.

Nuclear transport by EXTL3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →