EXTL2

Across TCGA patient cohorts, EXTL2 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,676 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible EXTL2-associated proteins across cancer lineages are DBN1, MARCKSL1, and BTK. Each is linked with EXTL2 in more than 5 cancer types. Because this analysis shows association rather than direction, both EXTL2-to-partner and partner-to-EXTL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EXTL2 versus DBN1 in LSCC, with a Pearson correlation of 0.50.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (EXTL2→partner) and Y-score (partner→EXTL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DBN1 →	+0.353	+0.465	<.001	<.001	3	6
GBM	MARCKSL1 →	+0.662	+0.422	<.001	<.001	3	6
LSCC	BTK →	-0.422	-0.488	.001	.006	3	5
LSCC	ADNP →	+0.294	+0.580	.007	.001	3	5
HNSC	CSTA →	-1.071	-0.658	<.001	.002	3	5
GBM	CTSS →	-0.524	-0.397	.004	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,676 associations by consensus.

EXTL2 vs DBN1 — LSCC

Explore this scatter interactively →