EXTL2

Across TCGA patient cohorts, EXTL2 protein abundance is significantly associated with the RNA expression of many other genes, with 8,596 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible EXTL2-associated genes across cancer lineages are TLR8, AIM2, and AADAT. Each is linked with EXTL2 in more than 4 cancer types. Because this analysis shows association rather than direction, both EXTL2-to-partner and partner-to-EXTL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EXTL2 versus TLR8 in HNSC, with a Pearson correlation of -0.27.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXTL2→partner) and Y-score (partner→EXTL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TLR8 →	-0.664	-0.404	.005	.001	3	5
LSCC	AIM2 →	-1.232	-0.630	<.001	<.001	3	5
HNSC	AADAT →	+0.870	+0.508	<.001	.001	3	4
LSCC	TNFRSF19 →	+1.146	+0.540	<.001	<.001	3	4
OV	GBP2 →	-1.118	-0.421	<.001	.003	3	4
UCEC	MSX1 →	+1.558	+0.478	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,596 associations by consensus.

EXTL2 vs TLR8 — HNSC

Explore this scatter interactively →