EXTL2

Across TCGA patient cohorts, EXTL2 mutation is significantly associated with the RNA expression of many other genes, with 2,330 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EXTL2-associated genes across cancer lineages are FAM219B, ZBTB7A, and C9orf50. Each is linked with EXTL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EXTL2-to-partner and partner-to-EXTL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM219B grouped by EXTL2-low versus EXTL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EXTL2→partner) and Y-score (partner→EXTL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FAM219B →	+0.429	+2.415	.002	.003	3	1
UCEC	ZBTB7A →	+0.331	+2.021	.001	.001	3	1
UCEC	C9orf50 →	-0.530	-2.392	<.001	<.001	3	1
UCEC	CCDC89 →	-0.724	-2.392	.001	<.001	3	1
UCEC	PTPN11 →	+0.517	+3.754	.005	<.001	3	1
UCEC	NSUN7 →	-0.557	-3.676	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,330 associations by consensus.

FAM219B by EXTL2 expression — UCEC

Explore this box plot interactively →